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Mouse Monoclonal to CD209

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Data sheet of Mouse Monoclonal to CD209

BrandExbio
Product typePrimary antibodies
ReactivityHuman
ClonalityMonoclonal

More info about Mouse Monoclonal to CD209

Brand: Exbio
Product no.: 11-640-C025
Product type: Primary antibodies
Host species: Mouse
Product name: Mouse Monoclonal to CD209
Antigen: CD209
Clonality: Monoclonal
Clone: UW60.1
Isotype: IgG1
Immunogen: CD209-His-tagged fusion protein
Format: purified
Specificity: The mouse monoclonal antibody UW60.1 recognizes human CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.
Categories: CD and Related Antigens (Human)
Concentration: 1 mg/ml
Storage buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage / stability: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Background: CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).
Purity: > 95% (by SDS-PAGE)
Purification: Purified by protein-A affinity chromatography
Product specific references: *Ryan EJ, Marshall AJ, Magaletti D, Floyd H, Draves KE, Olson NE, Clark EA: Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol. 2002 Nov 15;169(10):5638-48.
General references: *Geijtenbeek TB, Engering A, Van Kooyk Y: DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 2002 Jun;71(6):921-31., *van Kooyk Y, Geijtenbeek TB: A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev. 2002 Aug;186:47-56., *Khoo US, Chan KY, Chan VS, Lin CL: DC-SIGN and L-SIGN: the SIGNs for infection. J Mol Med. 2008 Aug;86(8):861-74.
Shipping condition: Room temperature

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