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Data sheet of HLA-DP/HLA-DR monoclonal antibody, clone Bra-14
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | IHC-P,IF,Flow Cyt |
More info about HLA-DP/HLA-DR monoclonal antibody, clone Bra-14
| Product description: | Mouse monoclonal antibody raised against native human HLA-DP/HLA-DR. |
| Clone: | Bra-14 |
| Isotype: | IgG3, kappa |
| Gene id: | 3115|3122 |
| Gene name: | HLA-DPB1 |
| Gene alias: | DPB1|HLA-DP1B |
| Gene description: | major histocompatibility complex, class II, DP beta 1 |
| Immunogen: | Human REH cells. |
| Protein accession: | P04440;P01903 |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 10 mM PBS. |
| Storage instruction: | Store at -20 to -80°C. Aliquot to avoid repeated freezing and thawing. |
| Specificity: | Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP and HLA-DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DP, DQ and DR, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles. |
| Size: | 100 ug |
| Shipping condition: | Dry Ice |