HLA-DRB1 monoclonal antibody, clone SPM423 View larger

HLA-DRB1 monoclonal antibody, clone SPM423

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Data sheet of HLA-DRB1 monoclonal antibody, clone SPM423

BrandAbnova
Product typePrimary antibodies
ReactivityHuman
ClonalityMonoclonal
Host speciesMouse
ApplicationsWB,IHC-P,IF,Flow Cyt

More info about HLA-DRB1 monoclonal antibody, clone SPM423

Product description: Mouse monoclonal antibody raised against native human HLA-DRB1.
Clone: SPM423
Isotype: IgG2b, kappa
Gene id: 3123
Gene name: HLA-DRB1
Gene alias: DRB1|FLJ76359|HLA-DR1B|HLA-DRB|HLA-DRB1*|SS1
Gene description: major histocompatibility complex, class II, DR beta 1
Immunogen: Activated human peripheral blood mononuclear cells.
Protein accession: P01911
Form: Liquid
Recommend dilutions: Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be d
Storage buffer: In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage instruction: Store at 4°C.
Note: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Specificity: This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Size: 100 ug
Shipping condition: Blue Ice

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