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Data sheet of HLA-DRB1 monoclonal antibody, clone SPM423
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | WB,IHC-P,IF,Flow Cyt |
More info about HLA-DRB1 monoclonal antibody, clone SPM423
| Product description: | Mouse monoclonal antibody raised against native human HLA-DRB1. |
| Clone: | SPM423 |
| Isotype: | IgG2b, kappa |
| Gene id: | 3123 |
| Gene name: | HLA-DRB1 |
| Gene alias: | DRB1|FLJ76359|HLA-DR1B|HLA-DRB|HLA-DRB1*|SS1 |
| Gene description: | major histocompatibility complex, class II, DR beta 1 |
| Immunogen: | Activated human peripheral blood mononuclear cells. |
| Protein accession: | P01911 |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d |
| Storage buffer: | In 10 mM PBS (0.05% BSA, 0.05% sodium azide). |
| Storage instruction: | Store at 4°C. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Specificity: | This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma. |
| Size: | 100 ug |
| Shipping condition: | Blue Ice |