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Data sheet of HLA-DRB monoclonal antibody, clone SPM289
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | WB,IHC-P,IF,Flow Cyt |
More info about HLA-DRB monoclonal antibody, clone SPM289
| Product description: | Mouse monoclonal antibody raised against native human HLA-DRB. |
| Clone: | SPM289 |
| Isotype: | IgG2b, kappa |
| Gene id: | 3123 |
| Gene name: | HLA-DRB1 |
| Gene alias: | DRB1|FLJ76359|HLA-DR1B|HLA-DRB|HLA-DRB1*|SS1 |
| Gene description: | major histocompatibility complex, class II, DR beta 1 |
| Immunogen: | Activated human peripheral blood mononuclear cells. |
| Protein accession: | P01911 |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d |
| Storage buffer: | In 10 mM PBS. |
| Storage instruction: | Store at -20 to -80°C. Aliquot to avoid repeated freezing and thawing. |
| Specificity: | This monoclonal antibody reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the HLA-DRB monoclonal antibody, clone SPM289, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. |
| Size: | 100 ug |
| Shipping condition: | Dry Ice |