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Data sheet of HLA-DQ monoclonal antibody, clone SPM422
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | IHC-P,IF,Flow Cyt |
More info about HLA-DQ monoclonal antibody, clone SPM422
| Product description: | Mouse monoclonal antibody raised against native human HLA-DQ. |
| Clone: | SPM422 |
| Isotype: | IgG2a, kappa |
| Gene id: | 3117|3118|3119 |
| Gene name: | HLA-DQA1 |
| Gene alias: | CD|CELIAC1|DQ-A1|FLJ27088|FLJ27328|GSE|HLA-DQA|MGC149527 |
| Gene description: | major histocompatibility complex, class II, DQ alpha 1 |
| Immunogen: | T4-positive CTL clone HG-38. |
| Protein accession: | P01908;P01909;P01920 |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 10 mM PBS. |
| Storage instruction: | Store at -20 to -80°C. Aliquot to avoid repeated freezing and thawing. |
| Specificity: | Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This monoclonal antibody strongly blocks cytotoxicity activity of T4+ cytotoxic T cell clones. |
| Size: | 100 ug |
| Shipping condition: | Dry Ice |