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Data sheet of HLA-B monoclonal antibody, clone SPM420
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | IF,Flow Cyt |
More info about HLA-B monoclonal antibody, clone SPM420
| Product description: | Mouse monoclonal antibody raised against native human HLA-B. |
| Clone: | SPM420 |
| Isotype: | IgG3, kappa |
| Gene id: | 3106 |
| Gene name: | HLA-B |
| Gene alias: | AS|HLA-B-7301|HLA-B73|HLAB|HLAC|SPDA1 |
| Gene description: | major histocompatibility complex, class I, B |
| Immunogen: | Normal human peripheral blood lymphocytes. |
| Protein accession: | P01889 |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 10 mM PBS. |
| Storage instruction: | Store at -20 to -80°C. Aliquot to avoid repeated freezing and thawing. |
| Specificity: | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. |
| Size: | 100 ug |
| Shipping condition: | Dry Ice |