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Data sheet of COL1A1 polyclonal antibody
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human,Mouse,Rat |
| Host species | Rabbit |
| Applications | IHC,WB-Ti,IF |
More info about COL1A1 polyclonal antibody
| Brand: | Abnova |
| Reference: | PAB17205 |
| Product name: | COL1A1 polyclonal antibody |
| Product description: | Rabbit polyclonal antibody raised against synthetic peptide of COL1A1. |
| Gene id: | 1277 |
| Gene name: | COL1A1 |
| Gene alias: | OI4 |
| Gene description: | collagen, type I, alpha 1 |
| Immunogen: | A synthetic peptide corresponding to amino acids at C-terminus of human COL1A1. |
| Protein accession: | P02452 |
| Form: | Liquid |
| Recommend dilutions: | Western Blot (1:1000) Immunohistochemistry (1:100) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 0.1 mg/mL BSA) |
| Storage instruction: | Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Antigen species / target species: | Human |
| Specificity: | This antibody has been directly tested for reactivity in human, mouse, rat and sheep. Based on the homology of the immunogen this antibody is expected to recognize the collagen I 1 polypeptide in all mammals, birds, and amphibians. specific to the ~ 140 KDa telopeptide portion of the collagen I 1 polypeptide. This antibody works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90°C in 10 mM sodium citrate (pH 6.0)/ 0.1% Tween-20). Note that in paraffin sections of formaldehyde-fixed fibrotic mouse lung tissue, This antibody recognizes mature collagen I that has formed fibrils in the extracellular matrix. |
| Reactivity: | Human,Mouse,Rat |
| Application image: |  |
| Application image note: | Immunostaining of formaldehyde-fixed fibrotic mouse lung tissue. The antibody recognizes mature COL1A1 (red) that has formed fibrils in the extracellular matrix. Using COL1A1 polyclonal antibody (Cat # PAB17205). |
| Applications: | IHC,WB-Ti,IF |
| Shipping condition: | Dry Ice |
| Publications: | Oxidants produced by Methylglyoxal-modified Collagen Trigger ER Stress and Apoptosis in Skin Fibroblasts.Nowotny K, Castro JP, Hugo M, Braune S, Weber D, Pignitter M, Somoza V, Bornhorst J, Schwerdtle T, Grune T. Free Radic Biol Med. 2018 Mar 14;120:102-113. |