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Data sheet of GAB1 (phospho Y659) polyclonal antibody
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human,Mouse,Rat |
| Host species | Rabbit |
| Applications | WB,ELISA,IHC-P |
More info about GAB1 (phospho Y659) polyclonal antibody
| Brand: | Abnova |
| Reference: | PAB16972 |
| Product name: | GAB1 (phospho Y659) polyclonal antibody |
| Product description: | Rabbit polyclonal antibody raised against synthetic phosphopeptide of GAB1. |
| Gene id: | 2549 |
| Gene name: | GAB1 |
| Gene alias: | - |
| Gene description: | GRB2-associated binding protein 1 |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Y659 of human GAB1. |
| Protein accession: | Q13480 |
| Form: | Liquid |
| Recommend dilutions: | Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:4000) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide) |
| Storage instruction: | Store at 4°C for three months. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Antigen species / target species: | Human |
| Specificity: | This antibody detects endogenous levels of GAB1 only when phosphorylated at tyrosine 659. |
| Reactivity: | Human,Mouse,Rat |
| Application image: |  |
| Application image note: | Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma tissue using GAB1 (phospho Tyr659) polyclonal antibody (Cat # PAB16972). |
| Applications: | WB,ELISA,IHC-P |
| Shipping condition: | Dry Ice |
| Publications: | Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.Cunnick JM, Mei L, Doupnik CA, Wu J. J Biol Chem. 2001 Jun 29;276(26):24380-7. Epub 2001 Apr 25. |