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Data sheet of CHEK2 (phospho T68) polyclonal antibody
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Chimpanzee,Human |
| Host species | Rabbit |
| Applications | IP,ELISA,WB-Ce |
More info about CHEK2 (phospho T68) polyclonal antibody
| Brand: | Abnova |
| Reference: | PAB10034 |
| Product name: | CHEK2 (phospho T68) polyclonal antibody |
| Product description: | Rabbit polyclonal antibody raised against synthetic phosphopeptide of CHEK2. |
| Gene id: | 11200 |
| Gene name: | CHEK2 |
| Gene alias: | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53 |
| Gene description: | CHK2 checkpoint homolog (S. pombe) |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding T68 of human CHEK2. |
| Protein accession: | O96017 |
| Form: | Liquid |
| Recommend dilutions: | ELISA (1:10000-1:50000) Western Blot (1:200-1:2000) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide) |
| Storage instruction: | Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Quality control testing: | Antibody Reactive Against Synthetic Peptide. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Antigen species / target species: | Human |
| Specificity: | Reactivity occurs against human CHK2 pT68 protein and This antibody is specific to the phosphorylated form of the protein. Reactivity with non-phosphorylated human CHK2 is minimal by ELISA. This antibody does not cross-react with Chk2 phosphorylated at other sites. |
| Reactivity: | Chimpanzee,Human |
| Application image: |  |
| Application image note: | Western blot using CHEK2 (phospho T68) polyclonal antibody (Cat # PAB10034) shows detection of apredominant band at ~60 kDa corresponding to phosphorylated CHEK2 (arrowhead) in MCF-7 whole cell lysates after treatment with doxorubicin. CHEK2 phosphorylation was induced using increasing concentrations of the DNA damaging agent doxorubicin as indicated for 24 h prior to lysate production. Personal communication, Xiao HeYang, University of Oklahoma Health Sciences Center. |
| Applications: | IP,ELISA,WB-Ce |
| Shipping condition: | Dry Ice |
| Publications: | A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH. Curr Biol. 1999 Jan 14;9(1):1-10. |