Brand: | Abnova |
Reference: | MAB6927 |
Product name: | CTLA4 monoclonal antibody, clone ANC152.2/8H5 |
Product description: | Mouse monoclonal antibody raised against CTLA4. |
Clone: | ANC152.2/8H5 |
Isotype: | IgG1, kappa |
Gene id: | 1493 |
Gene name: | CTLA4 |
Gene alias: | CD152|CELIAC3|CTLA-4|GSE|IDDM12 |
Gene description: | cytotoxic T-lymphocyte-associated protein 4 |
Immunogen: | A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein. |
Form: | Liquid |
Recommend dilutions: | The optimal working dilution should be determined by the end user. |
Storage buffer: | In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate) |
Storage instruction: | Store at 4°C. |
Product type: | Primary antibodies |
Host species: | Mouse |
Antigen species / target species: | Human |
Specificity: | MAB6927 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory cells in Vitro. It can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. |
Reactivity: | Human |
Application image: |  |
Application image note: | CTLA4 monoclonal antibody, clone ANC152.2/8H5 (Cat # MAB6927) blocked the binding of recombinant CTLA4-muIg fusion protein/R-PE conjugate to CD80 and CD86 expressed on human Raji cells. |
Applications: | EIA,Flow Cyt |
Shipping condition: | Blue Ice |
Publications: | Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells.Kitani A, Chua K, Nakamura K, Strober W. J Immunol. 2000 Jul 15;165(2):691-702. |