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Data sheet of Lbp monoclonal antibody, clone biG 33
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Mouse,Rat |
| Host species | Mouse |
| Applications | WB,ELISA |
More info about Lbp monoclonal antibody, clone biG 33
| Brand: | Abnova |
| Reference: | MAB5664 |
| Product name: | Lbp monoclonal antibody, clone biG 33 |
| Product description: | Mouse monoclonal antibody raised against recombinant Lbp. |
| Clone: | biG 33 |
| Isotype: | IgG1 |
| Gene id: | 16803 |
| Gene name: | Lbp |
| Gene alias: | Ly88 |
| Gene description: | lipopolysaccharide binding protein |
| Immunogen: | Recombinant protein corresponding to mouse Lbp. |
| Form: | Lyophilized |
| Recommend dilutions: | ELISA (1:50000) The optimal working dilution should be determined by the end user. |
| Storage buffer: | Lyophilized from PBS. |
| Storage instruction: | Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Antigen species / target species: | Mouse |
| Specificity: | The monoclonal antibody biG 33 reacts highly specific with mouse natural and recombinant LBP. This antibody is a type I antibody blocking the LPS binding to LBP. LPS binding protein (LBP) is an approximately 60 KDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. |
| Reactivity: | Mouse,Rat |
| Applications: | WB,ELISA |
| Shipping condition: | Dry Ice |
| Publications: | A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation-and obesity-associated adipose tissue dysfunction.Moreno-Navarrete JM, Escote X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Fruhbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernandez-Real JM Diabetologia. 2013 Aug 21. |