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Data sheet of CD28 monoclonal antibody, clone CD28.2
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | Flow Cyt |
More info about CD28 monoclonal antibody, clone CD28.2
| Product description: | Mouse monoclonal antibody raised against native CD28. |
| Clone: | CD28.2 |
| Isotype: | IgG1 |
| Immunogen: | Native purified CD28 from transfected murine cell line. |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (20ul/5x105 cells) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In PBS (2mg/mL BSA, 0.09% sodium azide) |
| Storage instruction: | Store at 4°C. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Specificity: | CD28 is a T-cell surface homodimeric 44KDa molecule that belongs to the Ig superfamily (1). CD28 is involved in cell adhesion T-B through the binding to its ligand B7/BB1, which is also the ligand for CTLA-4. CD28-B7 interaction is an important cosignal that allow T-cell proliferation and lymphokine production. CD28 is associated to a PI3 kinase activity (2). The majority of CD4+ T-cells and 50% of CD8+ T-cells express CD28 (3). The CD28.2 monoclonal antibody induces T-cell proliferation in costimulation with CD2 monoclonal antibodies (2). It also inhibits the CD4+ proliferation in the allogeneic T-cell response (2). This antibody has been studied at the Vth International Workshop on human Leucocyte Differentiation Antigens in Boston (1993). |
| Size: | 100 Reactions |
| Shipping condition: | Blue Ice |