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Data sheet of CTNNB1 monoclonal antibody, clone BDI480
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Dog,Human,Mouse |
| Host species | Mouse |
| Applications | ELISA,ICC,WB-Ce,IHC-P,EIA |
More info about CTNNB1 monoclonal antibody, clone BDI480
| Brand: | Abnova |
| Reference: | MAB3925 |
| Product name: | CTNNB1 monoclonal antibody, clone BDI480 |
| Product description: | Mouse monoclonal antibody raised against synthetic peptide of CTNNB1. |
| Clone: | BDI480 |
| Isotype: | IgG1 |
| Immunogen: | A synthetic peptide corresponding to CTNNB1. |
| Form: | Lyophilized |
| Recommend dilutions: | ELISA (0.05 ug/mL) Western Blot (0.5 ug/mL for HRP/ECL detection) Immunocytochemistry (1-10 ug/mL) The optimal working dilution should be determined by the end user. |
| Storage buffer: | Lyophilized from 2x PBS (PEG, sucrose, 0.09% sodium azide) |
| Storage instruction: | Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Specificity: | Specifically interacts with beta-catenin. The alpha-, beta- and gamma-catenins are cytoplasmic proteins mediating the interaction of Ca2+ -dependent transmembrane adhesion molecules (cadherins) with the cytoskeletal network. The direct interaction of beta-catenin with the cytoplasmic domain of cadherins plays a crucial role for cell-cell adhesion and signal transmission between neighboring cells. Recent studies indicate that beta-catenin may also play a role in tumorigenesis since it forms complexes with the tumor suppressor gene product APC. Beta-catenin directly interacts and constitutively activates transcription factors of the TCF/LEF gene family. Thus it is proposed that beta-catenin plays a dual role not only in the maintenance and regulation of cell-cell interactions but also in the regulation of gene activity. Cross reacts with human, mouse and dog. |
| Reactivity: | Dog,Human,Mouse |
| Application image: |  |
| Application image note: | Detection of endogenous CTNNB1from whole cell lysates of serum starved tumor cells (20,000 cells per lane). The blot was probed with 0.5 ug/mL CTNNB1 monoclonal antibody, clone BDI480 (Cat # MAB3925) for 1 hour at RT and developed by ECL (exp. time : 30 sec). Lane 1 : A-431. Lane 2 : SW480. Lane 3 : SW620. Lane 4 : HT-29. Lane 5 : MCF-7. Lane 6 : MDA-MB-231. Lane 7 : T-47D. |
| Applications: | ELISA,ICC,WB-Ce,IHC-P,EIA |
| Shipping condition: | Dry Ice |